Contract Research: Accelerate the pace of your R&D in HR or NHEJ.

Our group has >20 yrs. experience in the area as a Contract Research Organization and we stand behind our results. We guarantee clear, cosmetic data and unambiguous interpretations. You will receive a publication quality product. We are seasoned veterans in the arena of cell-based testing. More importantly, we can help you develop a tractable strategy for analysis of drug mechanisms in the context of your specific tumor cell model. We can evaluate potential genotoxic and genome stability mechanisms operable in either NHEJ (error prone DNA repair) or in HR repair (high fidelity pathway). Finally, all our systems are tractable and well defined using specific pathway reporter genes. We do not screen using extracts. Controls with specific drugs can be included to guarantee specificity in all assays and validate even negative results with unknowns. We save our clients considerable time and labor by offering services that are designed as a multi-tier approach to testing. For example, a limited scope screen (1-3 concentration inputs) is reasonable to quickly assess potential targeting. If the results are clearly negative, there is no need for follow-up. If we obtain a hit, we will work closely with you to design next logical steps in the project. 

Contact us for a quote at info@topogen.com and let us know how we can help you with your project on any aspect of DNA repair research.